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For some, these issues follow periods of intense stress, hormonal shifts, illness, or disrupted sleep

[DOI] [PubMed] [Google Scholar] 76.Anisimov V.N., Khavinson V.K., Zavarzina N.I., Zabezhinski M.A., Zimina O.A., Popovich I.G., Shtylik A.V., Arutiunian A.V., Oparina T.I., Prokopenko V.M

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Unknown parameters are treated as fixed values, inference is based on hypothesis testing against a null hypothesis to calculate the probability of observing the data (or more extreme data) under the assumption that the null hypothesis is true