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Description

Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay

Both groups followed a reduced-calorie diet, increased physical activity, and monthly nutritional counseling

doi: 10.1016/j.biopha.2018.10.021

Therefore, our findings showing that ubiquitylated IL-1, akin to the IL-1 K133A or D129A mutants, is inefficiently cleaved by Caspase-1 raises the interesting possibility that IL-1 K133 ubiquitylation impacts the integrity of the K133:D129 electrostatic interaction to limit caspase-1 processing