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In a rat model, melatonin demonstrated inhibition of NMDA receptor activation and subsequent NMDA receptor-mediated Ca 2+ entry into striatal neurons, suggesting a potential protective role [79]

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The therapeutic concentration for the antipyretic effect of acetaminophen is between 10 and 20 micrograms/mL (66 to 132 micromoles/L), but therapeutic concentrations for analgesia are not established

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