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All these events ultimately result in hepatocellular necrosis, although recent studies have also suggested the importance of necroptosis 14,15,16,17,18

Repeated bouts of sustained muscle contraction induce transient endocrine pulses rather than chronic elevations, favoring anti-inflammatory and neurotrophic signaling while simultaneously improving glycemic control and blood pressure, two major upstream determinants of DR progression (28, 110, 176)

However, the experimental results and the potentially synergistic effect can be strongly dependent on the experimental design

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