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It thus attains a high binding avidity for Axin with which it co-polymerizes through Axins DIX domain (designated DAX), thereby recruiting Axin together with GSK3 and other degradasome components to the cytoplasmic tail (ctail) of LRP6, as elaborated below

Mller W, Leistner E

Recognized by Castle Connolly, Super Doctors, The New York Times, and New York Magazine, she is consistently rated among New York Citys top dermatologists for her dedication and expertise

Mitochondrial dysfunction is now recognized as a major contributor to the poor outcomes of brain stroke, and medications targeting mitochondria may exhibit beneficial effects