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High concentrations of acetate and butyrate have been shown to alter tight-junction proteins and histone acetylation patterns in cervical epithelial cells, potentially facilitating viral entry and supporting HPV persistence

Splenectomized 4.2 / mice treated with mitapivat had significant reductions in Vcam1, Icam1, and Tbx expression in isolated aorta compared with splenectomized 4.2 / mice (Figure 6F and Supplemental Figure 10C)