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Levothyroxine (T4) should never be taken without T3 since conversion from T4 to T3 is often compromised in chronic illness

Studies in the literature often report only total glutathione levels (and use the unfortunate shorthand of calling it GSH rather than total glutathione), which masks potentially important data about the GSH:GSSG balance

The RAPID and RAPID Open Label Extension (RAPID-OLE) studies represent the largest multicenter randomized placebo-controlled trials conducted on this therapy