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Preventive management includes avoiding triggers and using migraine prophylactic medication, which can include 69 : Beta-blockers Tricyclic antidepressants Anti-seizure medications Serotonin-norepinephrine reuptake inhibitors (SNRIs), particularly when vestibular symptoms predominate (can worsen headaches) Verapamil, when vertigo manifests in the context of migraine aura For acute attacks of vertigo, the following vestibular suppressants can be considered 69 : Antihistamines Antiemetics Benzodiazepines Mnire Disease Initial therapy in Mnire disease should be dietary and lifestyle adjustments

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2, the NADPH homeostasis is mainly regulated by several metabolic pathways and enzymes including NAD kinase (NADK), the pentose phosphate pathway (PPP), the folate-mediated one-carbon metabolism, malic enzymes (ME), the nicotinamide nucleotide transhydrogenase (NNT), cytosolic or mitochondrial NADP-dependent isocitrate dehydrogenase (IDH1 and IDH2), the glutamine metabolism, and the fatty acid oxidation (FAO)