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IFN also induces an increase in barrier permeability through the reduction of ZO-1 and occludin expression in an adenosine monophosphate-activated protein kinase (AMPK)-dependent pathway, irrespective of the cellular energy levels 62

These findings suggest a potential link between the altered lipid metabolome in aging and the lipid dysregulation observed in AD, highlighting the need to further investigate how age-related lipid changes may contribute to AD pathology

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Consequently, the exact role of SHBG in neurodegenerative diseases and its clinical translational value require further validation through rigorously designed studies