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For Fitzpatrick types IV to VI, the safest and most effective approach usually avoids aggressive IPL and instead combines Pico laser at conservative settings or microneedling with PDRN, gentle mandelic or low-glycolic peels, and prescription topical and oral brighteners, all under strict sun protection

who demonstrated that rotenone treatment of mouse bone marrow-derived macrophages (BMDMs) primed NLRP3 inflammasome activation [55]

In tumors, the expression and activity of LOX undergo changes, and cancer cells reshape the extracellular matrix by secreting LOX, creating an environment more conducive to cancer cell metastasis (106)

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