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Decreased renal uric acid elimination is the primary driver of hyperuricemia in gout in ~90% of cases

10.1016/j.bbapap.2019.07.013 416 MitreaD

Furthermore, dysfunction of the heme-centric negative regulatory system of iron metabolism weakens its feedback inhibition on iron accumulation and iron toxicity (14)

The phase 3 trial is in 8,000+ patients with established cardiovascular disease and elevated Lp(a) with a hard primary endpoint composite of cardiovascular death, myocardial infarction, stroke, or urgent coronary revascularization requiring hospitalization