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We suspect that the reduced recognition of fully complementary targets by ZSWIM8 also helps explain the high efficacy and long duration of small interfering RNA therapies 58

This is reflected in the UK guidelines, which state that in the presence of discordance between the test results and strong clinical features of deficiency, treatment should not be delayed, to avoid neurological impairment. To us as chiropractors, missing a diagnosis of a functional B12 deficiency may mean the difference between a successful treatment for low back pain or a failure