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10.1038/s41584-023-00947-z 125 PradeepC

With mutagenesis studies, we propose an acyl-modification driven ghrelin-binding model, in which the binding of octanoyl group in cavity II orients the N-terminus of ghrelin to cavity I, and leads to the initiation of signal transduction

Therefore, in this study, we tested the hypothesis that administration of DHEA may alleviate APAP-induced hepatic damage by attenuating oxidative stress, inflammation, and apoptosis through stimulating SIRT1