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Description

Transglutaminase 2 crosslinks the glutathione S-transferase tag, impeding proteinprotein interactions of the fused protein

The resultant oxidative stress induces macromolecular oxidation of proteins, lipids and DNA/RNA, leading to lipid peroxidation of biomembranes, denaturation of intracellular proteins and enzymes and DNA damage

The SS-31-modified DOX-loaded liposome delivery system LS-DOX can effectively cross the blood brain barrier (BBB) to target gliomas, and mitochondrial targeting of SS-31 can enhance cellular uptake (182)