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Description

And so the whole process is called oxidation

From the condensation of 4-nitrophthalic anhydride (47) with 3-aminopiperidine-2,6-dione trifluoroacetate, followed by reduction of the product formed (48) , it is possible to obtain the 5-aminothalidomide derivative (49) by an alternative route (Scheme 8) 101

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