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Similarly, treating the DRG neurons with paclitaxel significantly hampered microtubule dynamics, promoted the formation of retraction bulb-like structures at the distal growing tips (Gornstein and Schwarz, 2017), and thus markedly impaired the neurite outgrowth of cultured DRG neurons (Chine et al., 2019a)

Another important function of GSH is to detoxify reactive electrophiles such as 4HNE 81

In addition, knockout of hepatic CYP 450 reductase could exacerbate triptolide -induced toxicity in mice (Xue et al., 2011), while pretreatment with CYP3A inducer of dexamethasone could protect against triptolide originated liver injury in rat (Ye et al., 2010), suggested CYP 450s mediated the metabolic activation of triptolide, leading to hepatotoxicity