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Protein kinase C (PKC)-mediated phosphorylation of heat shock protein family B (small) member 1 (HSPB1/HSP25/HSP27) limits the cytoskeleton-mediated iron uptake and therefore limits ferroptotic cancer cell death

Journal of Investigative Dermatology.

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Both screening approaches led to the identification of hit compounds that were able to reduce NS3-NS5 binding in vitro in a dose-dependent manner, as measured by an ELISA-based assay