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To ensure the tumor specificity of bsAb, the CD63 arm of bsHER2xCD63 should not bind and internalize in absence of a tumor-specific arm

Neurons and astrocytes both preferentially express the mitochondrially-located, kidney-type glutaminase (GLS) isoenzyme type 1 (GLS1), although there is also the liver-type GLS2 that localizes to the mitochondrion and nucleus (Cardona et al., 2001

To improve outcomes, an integrated, patient-centered approach that combines mechanistic insights, individualized treatment, and digital health tools is essential

Interestingly, female hPPAR mice exhibited a substantially lower levels of both basal and PFOA-induced steatosis compared to their male counterparts