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Yet, high drug development failure rates reflect an incomplete understanding of upstream molecular regulators of mitochondrial fate

Hepatology 39 , 892899 (2004)

Given the central role of oxidative stress in both acute injury and long-term remodeling, modulation of redox pathways represents a critical therapeutic objective (43)

(d) Quantification of regulated bone marrow adipose tissue in the tibia (rBMAT, above the tibia/fibula junction) and constitutive bone marrow adipose tissue (cBMAT, below the tibia/fibula junction) with osmium staining and computed tomography