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10.1083/jcb.200407053 J

Int J Dev Neurosci 25, 367372 (2007)

The methylation cycle is deeply intertwined with immune regulation, histamine clearance, and even the structural integrity of our tissues, making L-5-MTHF highly relevant for patients dealing with hyperactive immune responses and hypermobility: Mast Cell Activation Syndrome (MCAS): Histamine is broken down in the body by an enzyme called HNMT, which relies entirely on SAMe (S-adenosylmethionine) to function