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Reduce if gastrointestinal symptoms remain severe after six or more weeks at a given dose level, if significant dehydration results from persistent vomiting or diarrhea, if heart rate increases beyond 15 beats per minute above baseline, or if the side effect burden is causing protocol abandonment

Research suggests it may influence the expression of numerous genes associated with collagen synthesis, elastin production, antioxidant defense, and the maintenance of healthy connective tissue

Murine infection studies further reveal a critical T-Mac role in tissue damage and inflammation caused by bacterial infection