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Mood and behavioral conditions associated with high activity of serotonin and dopamine may or may not include the following: Common Symptoms of Overmethylation ADHD Depression Panic Disorder Paranoia Obsessions without compuslions Schizophrenia Insomnia Low academic motivation Low competitiveness High pain threshold Verbosity, rapid speech Grandiosity if psychotic Religiosity Nervous legs Low libido Tinnitis Signs of Overmethylation Responds well to folic acid supplements and niacin supplements Absence of seasonal allergies Food or chemical sensitivity Antihistamine intolerance Adverse reaction to SSRI's Adverse reaction to SAMe and methionine Elevated plasma levels of SAMe and methionine Dry eyes and mouth Tendency to being overweight Responds well to benzodiazepines Low blood histamine Low blood basophils Because depression can be caused by undermethylation (low serotonin depression) as well as overmethylation (high serotonin depression) biochemical biotypes, it can be extremely helpful to know your methylation status prior to taking medications to treat depression

Phytochemistry 69 , 11281134 (2008)

Osteoporosis: increased thyroid hormone levels can lead to decreased bone density (Delitala et al

Soil pH dominates elevational diversity pattern for bacteria in high elevation alkaline soils on the Tibetan Plateau