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Additionally, akin to the response to increased energy intake, nutrient deprivation has been shown as a potent inducer of p53 signalling in various cell types by upstream cues like AMPK signalling, fatty acids, or DNA damage 24,25,26,27

66,100 Taken together, the coexistence of multiple types of immune cell suggests a complex inflammatory microenvironment in neurofibroma, which could be associated with nerve injury 99 to promote tumorigenesis

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Researchers discovered that feeding probiotic live yeast to sea bass led to changes in the activities of antioxidant enzymes and gene expression (De et al., 2014)