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Allergic (hypersensitivity) reactions: itching, swelling of the face, lips, mouth, tongue, or throat, trouble breathing, anxiousness, low blood pressure, dizziness or fainting, headache, nausea, or skin rash

Sagiv A, Biran A, Yon M, Simon J, Lowe SW, & Krizhanovsky V

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The study showing copper peptides increased collagen in 70% of users versus 40% for retinoic acid suggests copper peptides may actually be more effective for collagen building specifically, though retinoids offer additional benefits (texture improvement, dark spot reduction) that copper peptides don't provide as strongly