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Oral TXA also improves the performance of adjuvant creams such as TC cream in melasma, with earlier clinical response [79]

Clinically, AS also overlaps with related disorders such as inflammatory bowel disease, psoriasis, and reactive arthritis, and patients may present with features like uveitis (eye inflammation), enthesitis (tendon/ligament insertion pain), or peripheral joint symptoms rather than textbook low-back complaints