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[PubMed] [Google Scholar] 195.Ohbo Y., Fukuzako H., Takeuchi K., Takigawa M

Degeneration of mesencephalic dopaminergic neurons in klotho mouse related to vitamin D exposure

When neuronal mitochondrial dysfunction leads to decreased OXPHOS efficiency, astrocyte-derived lactate can enter neuronal mitochondria via MCT2, converting to pyruvate for participation in the TCA cycle, thereby generating ATP to maintain neuronal membrane potential and synaptic activity (195)

From the 3348 subjects of the NESDA cohort, we aimed to select healthy controls (without any lifetime depressive/anxiety disorder) and those with a diagnosis of MDD at their baseline assessment