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Two single nucleotide substitutions detected in the SSTR2 promoter sequence at positions 83 and 57 from the major transcription initiation site were not associated with differences in clinical characteristics, hormonal profile, or responsiveness to SS ( Finally, the expression of a truncated variant of SSTR5 (SST5TMD4) that shows a preferential intracellular localization but is able to mediate signal transduction ( in vivo ( Post-Receptor Alterations Beside alterations in SS and DA receptors, defects in the downstream signaling pathways activated by these receptors might be involved in the pharmacological resistance of pituitary tumors

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