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The altered autoregulation of blood flow cannot meet the metabolic demand of tissues in ME/CFS, leading to tissue hypoxia and subsequent ischaemia/reperfusion injury with its associated symptoms and signs ( Endothelial damage Endothelial cells are important regulators of the immune system (308)

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Hepatology 67(2):549-559

Quercetin and tangeretin primarily enhance mitochondrial biogenesis by activating the AMPK/PGC1-/NRF1/transcription factor A, mitochondrial (TFAM) signaling pathway, which increases mitochondrial DNA replication and gene transcription