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European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology, 39 (3), 403413

Rate-limiting steps of the biosynthetic pathways in combinatorial whole-cell catalysts might not be the same as those in the original hosts, due to the different protein expression levels, enzymatic activities and substrate or cofactor levels in the engineered host cells

Viral infection impairs innate host defense Viral ORF3a interacts with heme oxygenase- 1 (HO-1) and reprograms heme metabolism leading to iron (Fe)-redox dysregulation (FeRD) during SARSCoV2 infection 27,45,46