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They share similarities in terms of signaling pathways, but the fundamental difference between the two lies in the fact that CARs possess an engineered scFv domain able to recognize tumor antigens not bound by MHC molecules and, instead, expressed directly on the membrane

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14 The FDA suggests that if a patient does not improve after 24 continuous weeks of Zoloft treatment, the dose be titrated upwards to see if the patient will see improvement at a higher dose

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