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GFP signals within the inner autophagosome membrane are degraded in the autolysosomes but mRFP signals are relatively stable and thus provide a visible measure of autophagic flux status 33

This also raises an unresolved question as to whether GSH efflux serves primarily as a permissive biochemical event or represents an actively regulated signaling step in apoptotic commitment

HSC2 exhibited elevated expression of several key genes, including the dopamine norepinephrine-converting enzyme Dbh , the hedgehog signaling modulator Hhip , as well as G-protein-coupled receptors that are targeted by vasorelaxation peptide hormones, Vipr1, Pth1r, Ramp1, Ednrb, and Agtr1a