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1, initial priming of the NLRP3 response upon antigen exposure involves recognition by toll-like receptors (TLRs) and NF-B-mediated transcription of genes coding for inflammasome components, including NLRP3, ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain), procaspase-1, in addition to pre-processed cytokines pro-IL-1 and pro-IL-18

Aryal, P., Hefner, C., Martinez, B

Its important to test for both homocysteine levels and the MTHFR gene variation because, while you may not have the gene that affects the methylation pathways, you may still have elevated homocysteine levels, which tells us the level of inflammation in our bodies

All claims regarding its biological activity are based on preclinical studies and are not supported by approved clinical data