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Choline can be supplied from diet, or made in the body as phosphatidyl choline via the PEMT enzyme There can be SNPS in PEMT, reducing activity, or it may be depleted by reduced methylation as it is SAMe-dependent

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Additional information Peer review information Nature Communications thanks Caryn Outten, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Inactivation of Rnd1 in mammary epithelial cells induced highly undifferentiated and invasive tumours in mice