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Phase I reactions are usually the initial steps in the biotransformation process, generating metabolites that can serve as substrates for Phase II conjugation reactions

The resolution of inflammation has emerged as a critical endogenous process that protects host tissues from prolonged or excessive inflammation, which can become chronic

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19S proteasome-associated DUBs comprise three members: USP14, UCH37, and RPN11, which show differences in ubiquitin chains removals and consequent protein degradation (Lee et al., 2011)