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Understanding this is the foundation for understanding why dosing is not a one-size-fits-all figure: the molecule behaves differently from the compounds people often group it with

Another form of renal toxicity, generally associated with NSAIDs, is seen in patients with prerenal conditions leading to the reduction in renal blood flow or blood volume, where the renal prostaglandins have a supportive role in maintaining renal perfusion

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Materials and Methods The study was a randomized, double-blind, placebo-controlled trial (registered at clinicaltrials.gov as NCT00641862)