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About one-third of patients with PSO eventually convert to PsA, and results from untargeted metabolomics studies have shown that patients with PsA have reduced serum BAs and Butyrate levels and increased levels of inflammatory lipid mediators (99)

Matrisome analysis on degenerated adult human samples showed fibrosis-like changes in the ECM due to ageing and degeneration as well as decreased solubility and changes in fibril diameter (Yee et al., 2016)

Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound

IBS, irritable bowel syndrome ROS, reactive oxygen species