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Here's a complete claim scenario that shows how it works in practice: A patient comes in with both knee pain and back pain

Additionally, the reputation of the journal in which the article was published was considered

PDGF, TGF-beta, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages