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In germ-free mice, colonization with this bacterium could restore the expression of key neurotransmitter-synthesizing enzymes in enteric neurons, including choline acetyltransferase, substance P, and nitric oxide synthase 70 .The gut microbiota maintains enteric nervous system integrity and regulates gastrointestinal function in a sex-independent manner via LPS and SCFAs 71

1b, Supplementary Table S2)

Clinical trial data from the SURMOUNT-1 study showed that up to 29% of participants on tirzepatide for weight loss experienced nausea, primarily during dose escalation phases

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