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E3 ubiquitin ligase CHIP interacts with transferrin receptor 1 for degradation and promotes cell proliferation through inhibiting ferroptosis in hepatocellular carcinoma

In breast cancer cell lines (MCF-7), activation of IGF/PI3K signaling enhances mitochondrial homeostasis by increasing the number of new mitochondria and levels of oxidative phosphorylation and promotes the degradation of damaged mitochondria (mitochondrial autophagy) by increasing BNIP3, a protective mechanism that ultimately influences the cancer treatment response and evolution of the cancer phenotype (53)

Sixthly, most of potential therapeutic interventions targeting ferroptosis for NAFLD are only utilized in animal studies, not in clinical practice, and ferroptosis inducers not only attack pathogenic cells, but also damage normal liver cells