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NAD+ metabolism and the control of energy homeostasis: A balancing act between mitochondria and the nucleus

10.1038/nrm1261 [DOI] [PubMed] [Google Scholar] Birchmeier C., Gherardi E

NNMT (nicotinamide N-methyltransferase) is upregulated in adipose tissue during obesity and metabolic dysfunction, where it actively depletes NAD+ by converting nicotinamide into N-methyl-nicotinamide for excretion