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A series of clinical trials showed that ICI could effectively induce tumor regression in a subset of advanced cancer patients

Phase 2b studies demonstrated tirzepatide produces HbA1c reductions of up to 2.4% versus placebo at 26 weeks (Thomas et al., 2021), with Phase 3 SURPASS trials confirming mean HbA1c reductions from baseline of 2.07 percentage points with tirzepatide 15 mg (treatment difference vs