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(b) NIR-I and (d) NIR-II Fluorescence intensity in tumor region at various time points (024 h) after i.v

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Data were expressed as permeability (Papp) calculated using the following formula: where dQ/dt, rate of permeation C 0 , initial concentration of compound A, area of monolayer (0.11 cm 2 ) Efflux Ratio (R e ) was calculated using the formula: 5.2

Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)