cagrilintide clinical trial results Scorecard: REDEFINE 1 and 2 New in the August 14,

New in the August 14, 2025, issue of NEJM: CagrilintideSemaglutide for Overweight or Obesity (REDEFINE 1 phase 3a trial) https: nej.md 444aW7f CagrilintideSemaglutide for Overweight and Diabetes (REDEFINE 2 phase 3a trial) https: nej.md 4ehQwLk In the REDEFINE 2 phase 3a trial involving adults with obesity and diabetes, the use of cagrilintidesemaglutide resulted in a significantly lower body weight than placebo at 68 weeks. Full trial results Efficacy and safety of co administered once weekly cagrilintide 24 mg with once weekly semaglutide 24 mg in type 2 diabetes: a multicentre, randomised, double blind, active controlled, phase 2 trial The Lancet ECO 2026 Assessing Cardiovascular Safety and Outcomes With the Combination of Cagrilintide and Semaglutide (CagriSema): REDEFINE 3 Randomised Clinical Trial Baseline Characteristics and Methods

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