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Thymosin Beta-4 itself is naturally present at high concentrations in platelets and at lower concentrations across many tissues

This is distinct from stimulants or acetylcholinesterase inhibitors, which modulate neurotransmitter availability rather than synaptic architecture

Further, the extraordinary affinity of HGF for Dihexa (Kd=2.2 x 10 "13 M) suggests that normally non- biologically active levels of HGF become physiologically relevant in the presence of a high affinity mimetic

Platelet-rich plasma (PRP) therapy, for example, provides a mixture of autologous growth factors and cytokines and has more established clinical evidence for certain applications