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Many studies including our studies have clearly shown that smoking is associated with endothelial dysfunction [42,43,44,45,46,47,48]

Flieger, E

doi:10.1039/c2ib00155a Chandrasekaran K, Swaminathan K, Mathan Kumar S, Clemens DL, Dey A (2012) In vitro evidence for chronic alcohol and high glucose mediated increased oxidative stress and hepatotoxicity