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Constipation is the most frequent autonomic feature affecting PD individuals and is determined by both neurogenic and non-neurogenic factors, such as reduced mobility and abdominal muscle tone, a diet poor in fibers and insufficient fluid intake, all contributing to a prolonged gastrointestinal transit time and sometimes megacolon [251]

There is no evidence that ingestion of unprotected SOD or SOD-rich foods can have any physiological effects, as all ingested SOD is broken down into amino acids before being absorbed

There is also an evidence suggesting inhibition of noradrenaline and dopamine reuptake by fluoxetine (Pozzi et al., 1999

Together with HSP70 and HSP90, sHSPs form an integrated chaperone network that buffers neurons against proteotoxic stress, delays aggregate formation, and promotes clearance of damaged proteins