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5-Rs isoforms (types 1, 2 and 3) are widely distributed in many tissues including the central nervous system, and inhibition of these enzymes results in blockade of synthesis of several key hormones and neuro-active steroids ( Figure ) leading to a host of adverse effects, including loss of or reduced libido, erectile dysfunction, orgasmic dysfunction, increased high Gleason grade prostate cancer (PCa), observed heart failure and cardiovascular events in clinical trials, and depression

5-Amino-1MQ works by precisely blocking the catalytic pocket of the NNMT enzyme

Key Features Directions for Use Adults: Squirt 1 spray under the tongue one to two times a day, or as professionally prescribed

Diarrhoea, nausea or vomiting