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RIPK1 undergoes phosphorylation instead of ubiquitination, triggering the activation of RIPK3, which subsequently phosphorylates the mixed lineage kinase domain-like pseudokinase (MLKL)

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This can occur at any level between the basolateral (sinusoidal) membrane of the hepatocyte and the ampulla of Vater

The plant-derived compound brusatol also decreases NRF2 protein levels (Ren et al., 2011), and use of any of these compounds improves sensitivity to chemotherapeutics such as cisplatin and gemcitabine