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doi: 10.3389/fonc.2021.780387 65 LiTLiY

(1) Subject to paragraph (b) of this section, the total rebate amount to be paid by a manufacturer for a Part D rebatable drug, identified as set forth in 428.101, for an applicable period is equal to: (i) The product of the per unit Part D rebate amount of such drug, as determined under 428.202(a), and the total number of units dispensed of such drug under Part D, as determined under 428.203

These initial changes typically manifest as improved skin hydration, a slight brightening effect, and enhanced skin texture

Adipocytes secrete bioactive substances, collectively termed adipokines [17, 34]