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Beyond its pathogenic influence, mtDNA also plays a role in shaping the course of pancreatitis through mechanisms that regulate cell survival, such as balancing apoptosis and necrosis, which are pivotal in determining the severity of the disease (115)

Nonetheless, there is still some room for improvement, namely developing a strategy with a variable rpm (scheduled or even adaptive), so that it can be adjusted according to process requirements

Exogenous Trx and intracellular Trx combine with MIF to form a complex which affects the MIF-induced inflammatory response

Its physiological concentration declines with age (from ~200 ng/mL at age 20 to ~80 ng/mL at age 60)